Below are links to the coordinates of recent depositions, pending curation by the PDB:
A New Collection of innovative articles with 3D interactivity has been launched by PLoS ONE.
The collection uses the iSee concept, developed in collaboration between the SGC and MolSoft to aid in drug discovery and design.
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PHF8 is a 2OG-dependent lysine demethylase with a selectivity for di- and mono-methylated histone 3 lysine 9 (H3K9) and di-methylated H3K27 and H3K36. Mutations in the PHF8 gene are associated with Siderius type X-linked mental retardation with or without a cleft lip/palate.
Here we present the crystal structure of PHF8, adding to the limited body of structural data for 2OG-dependent oxygenases.
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The SGC has a visiting scientist program in which external scientists, graduate students and postdoctoral fellows who have a position at another institution are invited to work within the SGC on proteins of mutual interest.
Structure of the atypical kinase haspin. Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein R, Murray J, Higgins J, Knapp S. PNAS. (2009) Dec 1;106(48):20198-203. Epub 2009 Nov 16.
