Prof. Stefan Knapp
Principal Investigator
Phosphorylation Dependent Signaling Group
Research activities in my group are focused on the functional characterization and structure determination of human kinases, phosphatases and other signaling molecules. The main interest my research is to understand the molecular mechanisms that lead to regulation of signal transduction and the development of specific inhibitors based on structural studies.
Curriculum vitae
| University education: | |
|---|---|
| 03.1987 - 08.1990 | Chemistry (University of Marburg (Germany)) Biochemistry (University of Illinois at Urbana). |
| 10.1991 - 09.1992 | Diplomathesis (Institute für Molekularbiologie und Tumorforschung) (IMT), University of Marburg (Germany), (Prof. M. Beato). |
| 11.1992 - 12.1996 | Ph.D. Thesis (Karolinska Institute) Department of Biosciences, Center for Structural Biochemistry, Stockholm, Sweden (Prof. R. Ladenstein). |
| 12.1996 - 12.1998 | Postdoctoral training: Karolinska Institute Unit for X-Ray crystallography, Stockholm (Sweden) |
| 06.1997 - 09.1997 | Guest Researcher (Université Paris-Sud) Institut de Génétique et Microbiologie Orsay Cedex, France. |
| Industrial Experience: | |
|---|---|
| 01.1999 - 01.2000 | Scientist, Pharmacia & Upjohn, Department of Biology, Nerviano, Italy. |
| 01.2000 - 04.2002 | Senior Scientist, Pharmacia Corp., Department of Structural Chemistry |
| 04.2002 - 02.2004 | Principal Scientist, Pharmacia Corp., Department of Chemistry. |
| Since 02. 2004 | Principal Investigator, Oxford University,
Nuffield Department of Medicine Structural Genomics Consortium (SGC). |
| Since 10. 2008 | Professor of Structural Chemistry, Oxford University, Nuffield Department of Medicine Structural Genomics Consortium (SGC). |
Current group members
- Jonathan Elkins
- Jeyanthy Eswaran
- Meera Soundarajan
- Peter Rellos
- Panagis Filippakopoulos
- Ivan Alfano
- Jing Wang
- Tracy Keates
- Eidarus Salah
- Sarah Picaud
- Ildiko Felletar
Phosphorylation Dependent Signaling Group
At the front from left to right: Jing Wang, Peter Rellos, Tracy Keates, Ildiko Felletar
At the back from left to right: Amalie Rudolf, Meera Soundarajan, Jeyanthy Eswaran, Stefan Knapp, Ivan Alfano, Panagis Filippakopoulos, Sarah Picaud, Eidarus Salah
At the front from left to right: Jing Wang, Peter Rellos, Tracy Keates, Ildiko Felletar
At the back from left to right: Amalie Rudolf, Meera Soundarajan, Jeyanthy Eswaran, Stefan Knapp, Ivan Alfano, Panagis Filippakopoulos, Sarah Picaud, Eidarus Salah
Selected Publications
- Barr, AJ, Ugochukwu, E, Lee, W-H., King, O, Filippakopoulos, P, Alfano, I, Savitsky, P, Burgess-Brown, N, Muller S, Knapp, S (2009). Structural and Functional analysis of the classical protein tyrosine phosphatase family (PTPome). Cell, 136(2):352-26
- Filippakopoulos, P, Kofler, M, Gish, GD, Salah, E, Neudecker, P, Kay, LE, Turk , BE, Pawson, T and Knapp, S. (2008) Structure of the Fps/Fes tyrosine kinase reveals cooperative interactions between the SH2-kinase domains and substrate. Cell, 134(5):793-803.
- Baumli, S., Lolli, G., Lowe, ED., Troiani, S., Rusconi, L., Bullock, AN., Debreczeni, JE., Knapp, S., Johnson LN. (2008). The structure of P-TEFb (cdk9/cyclin T), its complex with flavopiridol and regulation by phosphorylation. The EMBO J. 27,(13), 1907-1918.
- Marsden, B.D., and Knapp, S. (2008). Doing more than just the structure-structural genomics in kinase drug discovery. Current Opinion in Chemical Biology, 12, 40-45.